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What is NAD+ IV Therapy?

NAD Definition

NAD, short for nicotinamide adenine dinucleotide, is a coenzyme found in every cell within the body and is involved in numerous metabolic processes.

Using mitochondria it’s able to increase the length of telomeres, the protective caps located at the ends of chromosomes. They become shorter as the body ages and NAD increases the activity of SIRT1 and PARP 1 proteins, which are linked with a slower rate of aging and influencing DNA repair respectively (source).

How does NAD+ Work?

NAD levels naturally decline due to aging, stress, and environmental factors. NAD IV therapy delivers NAD+ and a blend of complimentary vitamins directly into the bloodstream, making it the most efficient and effective way to restore natural levels of this coenzyme.


Studies [1] [2] [3] [4] [5] have shown promising results that a coenzyme known as NAD can:

  • Slow down the aging process,
  • Improve mental clarity,
  • Restore neurologic function,
  • Ease the process of rehab and recovery,
  • Compliment depression and anxiety treatments,
  • Boost energy levels and reduce fatigue,
  • Enhance weight loss results by improving metabolic function,
  • Improve the body’s overall health.


NAD  is a coenzyme naturally found in every cell in the body that can maintain DNA integrity and reverse cellular damage.

 
One of its most significant roles within the body is in oxidation-reduction (redox) reactions. These reactions are a part of the metabolic system and converts food into the energy the body needs to function properly. The other important role that NAD plays is to regulate circadian and metabolic rhythm [1]. This coenzyme maintains DNA integrity and health and also functions as a quality control mechanism for new proteins.

Among other functions, NAD plays a significant role in anti-aging. NAD works on mitochondria and increases the length of telomeres, which are the protective caps located at the ends of chromosomes that become shorter as the body ages. NAD increases the activity of SIRT1 and PARP 1 proteins, which are linked with a slower rate of aging and influencing DNA repair respectively [2].

The body naturally produces NAD, but overall levels of the coenzyme decrease over time, leading to cellular changes that result in age-related pathologies. Lower levels of NAD and bonds between certain types of molecules are linked to damage to DNA which, left unrepaired, accumulate over time into cell changes and mutations [3]. Restoring and supplementing NAD counteracts many of these reactions and help preserve the integrity of DNA over time.

NAD Benefits and Uses

Research into the effects of NAD on the body is ongoing, but many studies have shown promising results of the benefits of NAD supplementation and restoration across a wide range of conditions.


NAD may help individuals who are:

  • Recovering from addiction and substance abuse: NAD helps reduce withdrawal symptoms and cravings. [1] [2] [3]
  • Interested in extending their lifespan: NAD is essential for DNA repair and plays a role in delaying the aging process. [1]
  • Interested in restoring neurological function: NAD may help restore brain function and reduce the risk of neurological disorders. [1] [2]
  • Experiencing cognitive decline: NAD may improve cognitive function and help with memory loss. [1]
  • Restore muscle function and improve athletic performance: NAD can improve muscle function and increase endurance, leading to better athletic performance [1]
  • Seeking to boost a weight-loss regimen: NAD can help increase metabolism and reduce inflammation, which can aid in weight loss. [1]
  • Seeking to reduce their fatigue and improve overall energy levels: NAD may improve mitochondrial function and increase energy production. [1] [2]
  • Slow the aging process: NAD is involved in DNA repair and plays a role in delaying the aging process. [1] [2]
  • Improve brain health: NAD may help protect brain cells, reduce the risk of neurological disorders, and improve brain function. [1] [2]
  • Improve mental clarity and clear brain fog: NAD may improve cognitive function and help with memory loss. [1]
  • Battle anxiety and depression: NAD may improve brain function and reduce symptoms of anxiety and depression. [1]


You don’t have to wait until you are experiencing a medical condition to experience the benefits of NAD IV therapy. This versatile treatment helps promote whole-body wellness and can help your body maintain optimal performance over time.


NAD IV treatments supplement and restore the levels of this powerful coenzyme in your body. A specialized saline solution containing a concentrated dose of NAD is delivered directly into the bloodstream, making it available to your cells for immediate use. Because NAD bypasses the digestive and metabolic systems, you can expect a 100% absorption rate for maximum effect and minimal waste.

NAD plays a major role in the aging process by regulating the circadian and metabolic cycles and acting as a regulator for new proteins. Changes in metabolism can lead to the development of certain age-related pathologies; NAD plays a role in the regulation of the Sir2p family, which influence lifespan and aging.

This coenzyme also helps protect the integrity of DNA, which becomes damaged over time from wear and tear, replication errors, and the damaging effects of free radicals. NAD is especially important in regulating inflammation that damages DNA over time. In addition, NAD can correct existing damage.

The body naturally produces NAD, but as the body ages, overall levels of this important coenzyme decrease and leads to the development of age-related conditions. Restoring and supplementing NAD in the body can improve physical appearance, health, and quality of life.


Benefits of NAD IV Therapy for aging related concerns include:

  • Reverse aging: While it’s not possible to reverse aging entirely, NAD+ can help slow down the aging process. By promoting cellular repair and regeneration, NAD+ can potentially help reduce the signs of aging and improve overall health and vitality.
  • Improve appearance: NAD+ can support healthy skin by promoting cellular repair and regeneration, reducing inflammation, and boosting collagen production. This can help improve skin texture, reduce wrinkles, and promote a more youthful appearance.
  • Restore muscle function: NAD+ is essential for muscle function and can help improve muscle strength, endurance, and recovery. By promoting mitochondrial function and reducing inflammation, NAD+ can help restore muscle function and reduce the risk of age-related muscle loss.
  • Restore athletic performance: NAD+ can help improve athletic performance by increasing endurance, reducing fatigue, and promoting muscle recovery. By supporting healthy mitochondrial function, NAD+ can improve energy production and help athletes perform at their best.
  • Reduce fatigue: NAD+ is involved in cellular metabolism and energy production, and can help reduce fatigue and improve overall energy levels. By supporting healthy mitochondrial function, NAD+ can help cells produce more energy and reduce feelings of tiredness and lethargy.
  • Boost energy levels: Similar to reducing fatigue, NAD+ can help boost energy levels by promoting healthy cellular metabolism and energy production. By increasing the availability of ATP (the body’s primary energy source), NAD+ can help improve physical and mental performance.
  • Boost metabolism: NAD+ is essential for cellular metabolism and can help boost metabolism by increasing the breakdown of fats and sugars for energy. By promoting healthy mitochondrial function, NAD+ can improve metabolism and support weight management.
  • Prevent damage to DNA: NAD+ is involved in DNA repair and can help prevent damage to DNA by repairing breaks and reducing oxidative stress. By supporting healthy DNA function, NAD+ can help prevent mutations and reduce the risk of age-related diseases.
  • Correct damage to DNA: In addition to preventing damage, NAD+ can also correct damage to DNA by promoting DNA repair and reducing oxidative stress. By supporting healthy DNA function, NAD+ can potentially reverse some of the damage caused by aging and environmental factors.


NAD is a holistic alternative to medication-based solutions for individuals undergoing addiction and recovery treatment. NAD is especially useful for patients who want to avoid the side effects of medications.


NAD detoxifies the body, replacing essential vitamins and nutrients that are typically depleted in individuals who engage in substance abuse. NAD reduces withdrawal symptoms by binding to opiate receptors, which can help individuals overcome cravings and risk of relapse. At the same time, this powerful coenzyme naturally protects the brain and accelerates recovery.


NAD also helps stimulate energy production, which helps combat the fatigue that typically occurs during detox. People in recovery often try to boost energy using sugar, caffeine, or other substances that can cause crashes or jitters. Improving the body’s energy levels naturally helps reduce the likelihood that individuals will attempt to boost energy using these methods. A recovery clinic in Los Angeles found that NAD helped patients significantly with symptoms like anxiety, depression, and cravings during withdrawal from alcohol and opiates.


Generally, NAD therapy to aid substance abuse disorder recovery involves multiple treatment sessions over a period of time. The frequency and duration of NAD treatment may vary depending on the drug(s) involved, as well as the severity of the addiction.


Benefits of NAD IV Therapy for Addiction and Recovery Include:

  • Fewer withdrawal symptoms: NAD can help reduce the severity of withdrawal symptoms during detoxification by supporting the production of neurotransmitters such as dopamine and serotonin, which are often depleted during addiction.
  • Reduce cravings associated with withdrawal: NAD therapy can help reduce cravings associated with withdrawal by supporting healthy brain function and reducing the imbalances in neurotransmitters that can lead to cravings.
  • Restored energy levels: NAD is involved in cellular metabolism and energy production and can help restore energy levels during addiction recovery. By supporting healthy mitochondrial function, NAD+ can help improve energy production and reduce feelings of tiredness and lethargy.
  • Improved mood: NAD can help improve mood during addiction recovery by increasing the availability of neurotransmitters such as serotonin and reducing inflammation in the brain. By promoting healthy brain function, NAD+ can help reduce symptoms of anxiety and depression.
  • Cell restoration: NAD can help restore cellular function and repair damage caused by addiction. By supporting healthy mitochondrial function and DNA repair mechanisms, NAD+ can help restore cellular health and reduce the risk of age-related diseases.
  • Improved brain function: NAD is essential for healthy brain function and can help improve cognitive function during addiction recovery. By supporting neurotransmitter synthesis and reducing inflammation in the brain, NAD+ can help improve brain function and reduce symptoms of cognitive impairment.
  • Improved cognitive clarity: NAD can help improve cognitive clarity during addiction recovery by promoting healthy brain function and reducing oxidative stress. By supporting healthy mitochondrial function and DNA repair mechanisms, NAD+ can help improve cognitive function and reduce the risk of cognitive decline.


A decrease in cognitive ability is a hallmark of aging. There are many age-related neurological conditions including dementia, decreased focus, and memory problems.


NAD helps keep the brain in top condition. This coenzyme rejuvenates and restores brain function by boosting sirtuins – proteins that function as anti-aging mechanisms that slow the effects of neurodegenerative diseases and natural cognitive decline. Together, NAD and sirtuins protect against toxicities in the body and improves cells’ resistance to stress.


NAD also combats inflammation in the brain that can contribute to cognitive decline. This damaging inflammation has also been linked to degenerative diseases like Alzheimer’s and Parkinson’s. Protecting brain cells from inflammatory damage preserves neuronal stress resistance and plasticity – the ability of the brain to adapt to changing environments.


NAD IV treatments can help maintain mental clarity, focus, protect mental clarity, and protect against neurodegenerative diseases for a healthier and happier quality of life.


Benefits of NAD IV Therapy for Neurological Conditions Include:

  • Improved brain health and neurological function: NAD supports healthy brain function by promoting healthy mitochondrial function and energy production, reducing inflammation, and supporting neurotransmitter synthesis. By improving the overall health of brain cells, NAD can help promote better brain health and neurological function.
  • Improved mental clarity: NAD can improve mental clarity by supporting healthy brain function and reducing oxidative stress. By promoting healthy mitochondrial function and energy production, NAD can help improve cognitive function and reduce mental fog.
  • Improved brain regeneration: NAD can help improve brain regeneration by supporting DNA repair mechanisms and promoting the growth of new brain cells. By supporting healthy mitochondrial function and reducing oxidative stress, NAD can help promote healthy brain regeneration.
  • Improved focus and concentration: NAD can improve focus and concentration by supporting neurotransmitter synthesis and reducing inflammation in the brain. By promoting healthy brain function, NAD can help improve cognitive function and reduce distractions that can interfere with focus and concentration.
  • Boosted mood: NAD can boost mood by increasing the availability of neurotransmitters such as serotonin and reducing inflammation in the brain. By supporting healthy brain function, NAD can help improve mood and reduce symptoms of anxiety and depression.
  • Improved memory: NAD can help improve memory by promoting healthy brain function and supporting neurotransmitter synthesis. By supporting healthy mitochondrial function and reducing oxidative stress, NAD can help improve cognitive function and reduce the risk of memory loss.


The term ‘metabolism’ refers to the amount of energy that is expended to maintain the body. The metabolism naturally slows with age and can lead to weight gain and lower energy levels. NAD plays a large role in normal metabolism function, which in turn helps improve weight loss and overall energy levels.


NAD plays an important part in the body’s oxidation-reduction (redox) reactions. These complicated chemical reactions are a part of the metabolic system and help convert food into energy that is usable by the cells. NAD accepts and donates electrons used in energy metabolism during the cellular respiration process.


NAD helps promote mitochondrial fitness by maintaining the mitochondrial unfolded protein response, a reaction to cell stress, by ensuring that these cells form into the correct shape for normal function. NAD helps the liver break down fats that are essential to provide energy for the body. It also helps create ATP, which is a major source of energy for cells.


Benefits of NAD IV Therapy for Metabolic Function Include:

  • Increased energy levels
  • Decreased fatigue
  • Restore muscle function and athletic performance
  • Improved metabolism
  • Weight loss


Weight Loss

NAD plays an important role in the body’s ability to manufacture and expend energy and is one of the body’s most critical metabolic cofactors. The functionality of our metabolism is influenced by variations in NAD levels. Our metabolism becomes sluggish and fat burning slows to a crawl when NAD levels are low.


NAD IV therapy is a modern and intriguing weight loss treatment designed to supercharge your metabolism to burn calories and fat efficiently. Restoring normal levels of NAD intravenously stimulates the conversion of food into a viable energy source, which is then recycled in order to burn calories, leading to noticeable weight loss.


Shedding those pounds is only part of the weight loss journey, and keeping them off is just as tough a task. NAD can help increase our resting metabolism, which is a crucial aspect of maintaining low fat reserves after significant weight loss.


In addition to contributing to weight gain, declining NAD levels are closely connected to several separate metabolic issues, such as fatty liver disease and diabetes. Maintaining healthy NAD levels can combat these issues and support your long-term well-being.


An active lifestyle featuring regular exercise, a balanced diet, and focus on getting a good night’s sleep can work wonders for your mood and general health, but there are moments in life where the prospects of anxiety and depression can still seem inescapable.


NAD can help elevate mood and counter symptoms of depression and anxiety. A recent study has suggested NAD IV therapy can also offset fatigue, a prevailing symptom of both depression and anxiety.

NAD is linked with adenosine triphosphate (ATP) production in the brain, where it is used to create beneficial neurochemicals. Anxiety reduces levels of NAD in the brain, as well as hormones such as serotonin that help regulate mood. Supplementing NAD can help the brain produce normal amounts of “feel good” neurochemicals even if a person is stressed or anxious, which helps improve symptoms.


Further, NAD helps detoxify the body, effectively eliminating drugs and other damaging substances, restoring your neurological health and providing a general sense of tranquility.


NAD therapy

IV NAD supplementation

NAD IV therapy involves the intravenous delivery of fluids and NAD into the body directly into the bloodstream. Other ingredients, like vitamins, can also be added to the solution.


Because treatments are delivered directly to the bloodstream, none are lost in the digestive process, which can result in up to 50% of nutrients or medications being broken down. This also allows treatments to start working right away, so you feel the benefits more quickly.


Finally, IV fluids help ensure you are properly hydrated, and help flush toxins from your body to ensure optimal function.


Pros:

  • Bypasses the digestive system, allowing for a high absorption rate
  • Hydrates in addition to supplementing NAD, and other nutrients may be added to treatment
  • Effects can last for months between booster appointments

Cons:

  • Most expensive NAD therapy option
  • Infusions can take 1-3 hours, depending on the dosage, and multiple sessions may be required over the course of several weeks
  • Not ideal for those with aversion or fear of needles

NAD injections

If you want the benefits of NAD administered directly into your bloodstream, but without the need to schedule an appointment for IV therapy, NAD injections may be right for you. 

After a consultation appointment determining if NAD injection treatment suit your needs, a quick injection is administered into to muscle.


Pros:

  • Bypasses the digestive system, ensuring a high absorption rate
  • Treatment is quick, lasting approximately 15 minutes
  • Less expensive than NAD IV therapy

Cons:

  • More expensive than oral supplements
  • Smaller dose, requiring more frequent treatments or maintenance

Oral NAD supplements

NAD capsules help people who prefer traditional oral treatments supplement NAD. This option is generally cheaper than IV therapy or injections, but requires continued use of supplementation.


Pros:

  • Typically safe without severe side effects
  • Does not involve uncomfortable administration methods
  • Most affordable NAD therapy option

Cons:

  • Studies are still underway regarding certain potential health benefits
  • Not ideal for those who have difficulty taking supplements or medications orally
  • Ingredients must be processed by the digestive system before they are bioavailable, meaning there is less NAD available overall

What is the recommended regimen?

NAD treatment typically includes a course of several infusions or injections administered over time.

The frequency of treatments depends on the dosage needed and is based on individual assessment.

It is recommended to receive an NAD+ IV prior to IM injections to help saturate the cells and to easily monitor how well the NAD+ IV is tolerated.

IM injections are ideal to be given in between IV infusions or after a treatment course to help maintain NAD levels in the body.


To achieve long-lasting and optimal results, it is generally recommended to undergo 2 sessions 2 weeks apart. Maintenance therapy of IV infusions every 3-4 months or injections every 2-4 weeks is beneficial.

Does NAD therapy have any side effects?

NAD supplementation is generally a safe and well-tolerated treatment with few side effects.


Most side effects are directly related to the speed at which the IV is infused at the time of the infusion. They can be relieved by slowing down the infusion. Side effects lessen with subsequent infusions.

These can include:

  • Headache or fullness/pressure in the head
  • Chest tightness
  • Anxiety feeling
  • Severe nausea/abdominal cramping


The majority of these are mild and tend to vanish quickly, but you should contact your doctor in the event of a serious symptomatic side effect, such as an allergic reaction or infection.

Conclusion

Nicotinamide adenine dinucleotide (NAD) is a fascinating molecule that is essential for cellular energy production, DNA repair, and cellular communication. With its role in supporting healthy mitochondrial function and reducing oxidative stress, NAD has been shown to have potential health benefits, such as reducing withdrawal symptoms during addiction recovery, improving brain function, restoring muscle function, and slowing down the aging process.


If you’re interested in exploring the potential benefits of NAD, it’s crucial to work with a licensed medical professional who can provide personalized guidance and help determine the best approach for your unique needs and goals. By taking advantage of NAD’s potential health benefits, you can unlock your body’s natural healing potential and take control of your health and wellbeing.

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